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Chapter digestive system drugs
1, anti-peptic ulcer drug cimetidine
[base] (Cimetidine, Tagamet)
Cimetidine (Tagamet)
[size tablet or capsule formulations: 0.2g; injection solution: 2ml: 0.2g.
response card] [peptic ulcer, upper gastrointestinal bleeding, but also for chronic pancreatitis and pancreatic cystic fibrous alterations, reflux esophagitis, gastrinoma and so on.
Pharmacokinetics] oral tmax of almost 45 ~ 90min, profitable in blood concentration continues 4h, biological discipline degrees approximately 70%, PB 5% to 20%. Drugs can be reabsorbed by the enterohepatic cycle, a division on behalf of the liver to open the other part of the prototype with the exclusion of urine, t1 / 2 of around 2h.
prevalent detrimental reactions, nausea, spewing, jaws pain, dry jaws, diarrhea, and abdominal distension. Also cited the starting of Halo, and additional signs of lethargy and vigor barriers. Large doses may arise from gynecomastia, galactorrhea, impotence and other ######ual subside alternatively, to alleviate the liver can reason liver patient collapsed. Can occasion liver break and ALT levels, understood as the Reversible inhibition of bone soul feature.
drug interactions with warfarin, theophylline, phenytoin, class and other drugs in combination, should reduce the dose. Such as aluminum hydroxide antacids or metoclopramide can reduce the absorption of the product. Can be cheap sucralfate, tetracycline, etc. character. With opioids applied, can generate chronic renal failure who inhibit suction aspiration, physical disorders, and set back force barriers should be reduced by the amount of opioid preparations.
Dosage for adults, oral: 0.2g / time, 3 times / day, later meal, ahead going to mattress and then served 0.4g; or 0.4g / times, 2 times / day; or 0.8g 1 ton service before working to mattress. Intravenous injection: 0.2g / second, sdefect in ...jection, 4 to 6 times / day. Intravenous drip: 0.4g ~ 0.6g, 2 times / day. Children: oral or intramuscular injection, each 5mg ~ 10mg/kg, 2 ~ 4 times / day.
Precautions Pregnancy Category B. This product and to liver and kidney changes are always reversible after discontinuation may regulate complex, but liver and kidney dysfunction should be used with caution. However, while Russia's restriction from the high acidity can make the ulcer even off hole, the other in the treatment of cancer should be elevated heaved before the ulcer. The goods and ranitidine, famotidine in the treatment plan to stop the emulating substitutions:
Ding famotidine for cimetidine Ray Monk
400mg / times, 2 times / day 150mg / times, 2 times / day 20mg / times, 2 times / day
800mg 300mg before bedtime bedtime bedtime
40mg per 300mg intravenously every 6h 8h Each 50mg intravenous injection 20mg
12h 24h taking 1200mg per each taking 150mg every 24h 24h taking 40mg
ranitidine [base] (metronidazole furosemide quack, get good at the stomach)
Ranitidine (Zantac)
[agents specification] tablet or capsule: 0.15g; injection: 50mg, 150mg.
indications] [peptic ulcer, reflux esophagitis,
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Pharmacokinetics] oral tmax of about 1 ~ 3h, biological interest cost of about 49%. t1 / 2 approximately 2.1 ~ 3.1h. Large departments Physiognomy secretion by the kidneys.
common adverse reactions headache and dizziness. Can cause elevated ALT may be cis (ranitidine hepatitis). Occasional fever, the male chest received training, nephritis, and intravenous injection site itching, redness, etc.
drug interactions with theophylline can be applied to the blood concentration, reduce Iranian straight itraconazole, ketoconazole, cefuroxime, diazepam and other drug absorption.
Dosage Oral, 0.15g / times, 2 times / day, early dinner service; or 0.3g Dayton clothes before going to bed; maintenance dose of 0.15g, Dayton clothing before going to bed. Zuo Linge - Ellison syndrome suitably large dose, 600mg ~ 1200mg / day. Intramuscular or slow intravenous injection, 25mg ~ 50mg / times, each 4 ~ 8h 1 times. Intravenous infusion, 100mg ~ 300mg. Children: oral, each 2mg/kg, 3 times / day.
Precautions Pregnancy Category B. Liver and kidney function decline should interfere dose.
famotidine [base] (surmise means D, high Serta)
Famotidine (Gaster, Pepcidine)
[agents specification] tablets or capsules: 20mg ; injection: 2ml: 20mg.
[indications] gastric and duodenal ulcers, in line with mouth ulcers, reflux esophagitis, upper gastrointestinal bleeding, Zuo Linge - Ellison syndrome.
Pharmacokinetics instruct] convincingly dead manipulate degree 50%, 1h attack, tmax of about 2h, t1 / 2 approximately 4.2h. PB is 15% to 22%, the first web secretion by the kidney, 24h dismiss rate of the drug in urine leave 88% to 91%.
adverse reactions are skin rash, gastrointestinal discomfort, neutropenia landing, a transient increase in ALT, blood oppression, pulse speed, color in flushing, headache, dizziness and hallucinations and other symptoms.
drug interactions can improve theophylline toxicity.
Dosage Oral: 20mg / times, 2 times / day, or 40mg at bedtime Dayton clothes. Or intravenous infusion: 20mg, 2 times / day. Maintenance dose of 20mg / day, before going to bed Dayton clothes.
PRECAUTIONS liver and kidney dysfunction, and pregnant women with caution in patients with previous ulcer should get rid of sarcoma. Dose increased to 60mg / day and then look the progress when ulcer healing rate.
nizatidine (love Greece)
Nizatidine (Axid, Nizax)
[proxies description] capsule: 150mg, 300mg.
[indications] deeds duodenal ulcer and gastric ulcer, duodenal ulcer is also used to guard opposition recurrence.
Pharmacokinetics] oral tmax of about 1 ~ 3h, t1 / 2 of 1 ~ 2h, biological control is greater than 90%, 90% of oral dose in the urine within 12h, there is a world 60 % of the fact.
Adverse reactions may comprise headache, dizziness, get nap, breast and behind pain, brawn center pain, nausea, vomiting, abdominal pain, ... constipation, rhinitis, vomiting inflammation, itching and sweating and so on, even blood uric acid and lifted transaminase.
drug interactions with cyclosporine in fusion, may addition liver toxicity.
Dosage Oral: Dayton clothing before going to bed 300mg, or 150mg / times, 2 times / day. Maintain the treatment 150mg / day, before going to bed Dayton clothing. Creatinine discontinue rate of 20ml ~ 50ml/min or less than 20ml/min, the dosage should be divided joined to 150mg / times, 1 time / day or 150mg / second,
Nike Shox R2, 1 / 2, to maintain dose is reduced to 150mg every other day or every 3 days 150mg.
Precautions Pregnancy Category C. Patients with renal insufficiency should dilute the dose.
omeprazole [base] (Oh m prazosin, Losec)
Omeprazole (Losec)
[agents specification] capsule: 20mg; injection: 40mg.
indications] [peptic ulcer, upper gastrointestinal bleeding, Zuo Linge - Ellison syndrome and reflux esophagitis and so on.
Pharmacokinetics] Oral absorption is not the same, the edible may delay its absorption, bioavailability fare of 70%. Mainly in the liver. Intravenous and oral administration of the t1 / 2 for 1h and identify 2 ~ 3h. About 80% of metabolites excreted by the kidney position, there is enterohepatic cycle process.
good response [not] malign widely, headache, back diarrhea, constipation and abdominal distension warfare, beneath the curious and see transaminase erase rash, drowsiness, dizziness, insomnia, etc.
delay the onset of drug interactions diazepam, a unattached nasal spray UEA, phenytoin, warfarin, nifedipine in the same half-life of delay. This product can significantly reduce the high gastric pH, increased days of digoxin may be the absorption of other drugs.
Dosage Oral or intravenous injection, 20mg / times, kor cups, 1 times / daytime. Zhuo - Ellison syndrome, he hopes to dose 60mg / daytime, as with 20mg ~ 120mg / day can control symptoms, the potion exceed 80mg / day should be divided into 2 doses.
Precautions Pregnancy Category C. Liver and kidney dysfunction, caution.
Lansuo shove yl [base] (NASDAQ Phlong)
Lansoprazole (Takepron)
[agents specification] capsule: 15mg, 30mg.
[indications] gastric and duodenal ulcers, anastomotic ulcers, Zuo Linge - Ellison syndrome and reflux esophagitis.
] [Pharmacokinetics after oral administration tmax of about 2h, without affecting food, bio-degree about 60% with 80%. PB about 98%. t1 / 2 approximately 1.5h.
adverse reactions are skin rash, itching and other eccentric reactions, as well as constipation, diarrhea, dry mouth, abdominal distension, headache, anemia, leukopenia, increased white blood compartments and eosinophilic reactions such as fever, infrequent insomnia .
inspire each other [drugs] Meet Olympic yl good waste.
Dosage Oral: 30mg / times, 1 time / day. Zuo Linge - Ellison syndrome the dose should be individualized, should be simply to reduce gastric acid secretion was maintained at 0 ~ 10mmol / h.
PRECAUTIONS liver dysfunction, productive women and lactating women, pearly antique man and my daughter accustomed with admonition.
proglumide (paraxylene glutamine)
Proglumide (Gastridine)
[agents specification] tablet: 0.2g; injection: 5ml: 0.4g.
stomach amphetamines tablets (umbra proglumide tablets): 0.1g with proglumide and appropriate painful grass, black Shao, borneol.
[indications] gastric and duodenal ulcers, gastritis, duodenal go distant, merely also for acute gastric mucosal lesions and acute upper gastrointestinal bleeding.
Pharmacokinetics] rapid and complete oral absorption, tmax of about 2h, mainly in the liver, kidney and gastrointestinal tract, chiefly excreted by the intestine and kidney, t1 / 2 approximately 33h. [adverse reactions]
constipation, diarrhea, headache, pruritus and dry mouth, etc., occasionally a temporary transaminase decreased slightly.
Dosage Oral: 0.4g / time, 3 to 4 times / day, managed 15min before a meal. Intravenous injection: 0.4g / times, 4 times / day.
[] common not only focus on single issues with proglumide treatment of ulcer disease.
pirenzepine hydrochloride (topiramate ulcer flat, piperazine pyridine nitrogen class, piperazine topiramate Zhuo ketone)
Pirenzepine Hydrochloride (Gastrozepin, Bisvanil)
[specifications] tablet formulations : 25mg, 50mg.
indications] [peptic ulcer, acute gastric bleeding and gastrinoma.
Pharmacokinetics] oral receiving lacking, about 26% degree of biological cheat the body scatter widely, PB 10%, and extra to talk the truth through the kidneys and bile leakage. t1 / 2 approximately 10 ~ 12h.
common adverse reactions, dry mouth, vision trance, diarrhea, constipation, nausea, headache, tremors and other clutter and energy, even there may be languid, listless, itching and so on.
drug interactions alcohol and coffee may reduce the role of the goods,
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Dosage Oral: 50mg ~ 75mg / times, 2 times / day, fasting 1.5h taking a maintenance dose of 50mg ~ 100mg / day.
Precautions Pregnancy Category X. Caution in patients with glaucoma and prostatic hypertrophy.
misoprostol front liquor (hi g ulcer)
Misoprostol (Cytotec)
[agents specification] tablet: 200? g.
[indications] to discourage non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal ulcers.
Pharmacokinetics] oral tmax of about 30 ~ 60min, PB is 80% ~ 90%,
Jordan Pro Classic, t1 / 2 of 1.55 ~ 1.8h. About 75% excreted by the kidneys.
adverse reactions indigestion, nausea, diarrhea, abdominal pain, headache.
drug interactions Antacids may eliminate the absorption of the product, and add this product's Diarrhea. Food can reduce absorption of the goods, but the achieve can be reduced Shen diarrhea.
Dosage Oral: 200? g /, 4 times / day way of 4 to 8 weeks.
] [Note for pregnancy Category X. With thinking vascular or coronary artery disease in patients with caution, disapprove of the chemicals were banned.
En prostaglandin
Enprostil (Gardrine)
[agents specification] capsule: 35? g.
indications] [peptic ulcer.
Pharmacokinetics] oral tmax of about 0.5 ~ 1h, eliminate biphasic, t1 / 2 parting of 1.8h and 34.3h.
Adverse reactions are mainly diarrhea, and different headache, nausea, constipation and abdominal pain.
Dosage Oral: 35? g / times, 2 times / day course of 4 to 8 weeks.
Precautions Pregnancy Category X.
Rosa epoprostenol
Rosaprostol (Rosal)
[agents specification] tablets: 500mg.
[indications] gastric and duodenal ulcers, continuing gastritis and duodenitis, stomach and duodenum of drug-induced damage.
adverse reactions occasionally nausea, vomiting and diarrhea.
Dosage Oral: 500mg / times, 4 times / day as 6 weeks. [focus on] materials
pregnancy Category X. Closing the trachea asthma, Xu, ease undergoing from obstructive lung patients with glaucoma be used with caution in patients fed up with the chemicals banned.
sodium bicarbonate [base]
Sodium Bicarbonate
[agents specification] tablet: 0.5g; injection: 10ml: 0.5g, 100ml: 5g, 250ml: 5g.
[indications] hyperacidity, indigestion.
adverse reactions are bloating, belching, blaze swelling, cerebral hemorrhage, metabolic alkalosis, hypernatremia and so on.
to do with each other [drugs] can be reduced with ketoconazole, iron, tetracycline and other drugs courses.
Dosage Oral: 0.5g ~ 1.0g / time, 3 times / day, meal service. Alkalization of urine while applied with sulfa drugs sulfa equal value with the service. Gastric lavage namely often dubbed a 2% solution.
Precautions Pregnancy Category C. Severely weakened patients with ulcers. Congestive heart failure and renal failure should not use acid poisoning. Intravenous incidence of hypocalcemia in patients with paroxysmal convulsions about, while the patient is able to produce potassium hypokalemia (eg, cardiac toxicity) symptoms.
aluminum hydroxide
Aluminum Hydroxide
[agents specification] tablet: 0.3g; gel: 4% (g / g) (dollars in three alumina ).
compound aluminum hydroxide tablets (Weishu taper piece Aluminum Hydroxide Co.): Each hydrogen alumina 0.245g, magnesium trisilicate 0.105g, Belladonna fluid extract 0.0026 ml.
stomach Shunin piece Aluminum Hydroxide et Saussurea): Each hydrogen alumina 0.07g, magnesium trisilicate 0.03g, magnesium oxide 0.067g, calcium carbonate, 0.134g, licorice extract 0.067g, belladonna liquid extract 0.0033 ml, Librium 0.01g, Baiji powder 0.1g, wood nasal spray 0.047g.
[indications] hyperacidity, peptic ulcer, reflux esophagitis, upper gastrointestinal bleeding and high phosphate hyperlipidemia and so on.
constipation common adverse reactions, dose-closed, when the trigger caustic intestinal prevention. Sustainable use of hypophosphatemia can happen, the amount of lax bone and bone sclerosis.
drug interactions with tetracycline drugs can affect the absorption of the same service. Warfarin can be nuisances, digoxin, dicoumarol, quinine, quinidine, chlorpromazine, Pu Nailuo I, indomethacin, with cloud hydrazine, vitamins and the absorption of barbiturates or exclude.
Dosage: oral gel 5ml ~ 8ml / 3 times / day, 1h before meals and at bedtime, the dose can be more solemn condition; tablets 0.6 ~ 0.9g / time, 3 times / day, the pain should be chewed before or after the service, when required before going to bed by 1. Weishuping films, 2 ~ 4 / 3 times / day, chew service. Stomach Shunin tablets, 2 ~ 3 / time, 3 times / day, nibble service.
[] should pay care to matters of magnesium oxide and magnesium trisilicate or Guadai use. Renal function may guide to missing the chief nervous system diseases such as smart. Treatment of bleeding when it is fitting gel. Of bile, pancreatic nectar and other mighty alkaline digest or inadequate absorption of hurt excretion should not be used.
sucralfate [base] (abdomen ulcer Ning)
Sucralfate (Ulcerlmin)
[agents specification] tablet or capsule: 0.25g.
WKN tablets: Each tablet including sucralfate with aluminum counted as 30.4mg ~ 42mg and berberine 45mg ~ 55mg.
[indications] gastric and duodenal ulcers.
Pharmacokinetics] first and foremost with the feces after oral administration, approximately 5% of absorption through the gastrointestinal tract, there is a small amount of sulfate disaccharide through the kidney row drum.
adverse reactions constipation, nausea, dry mouth, diarrhea, permanent doses can cause hypophosphatemia.
drug interactions using this service should not be taken within half an hour before antacids. Combined with the Multienzyme, both effects are reduced.
Oral Dosage: 1g / times, 4 times / day, before meals and before bedtime, for 3 months. WKN film for peptic ulcer, chronic or superficial gastritis, oral 5 /, 3 to 4 times / day, taken among two meals.
Precautions Pregnancy Category B. Constipation dissecting a tiny magnesium services, efficient management should be continued after taking a few months, so repetition.
aluminum magnesium carbonate [base] (stomach up to hi)
Hydrotalcite (Talcid)
[agents specification] savor tablet: 0.5g.
[response card] gastritis, duodenal ulcer refers to twelve, stomach acid reflux, stomach acid excess breeds of gastritis.
adverse reactions indigestion, gastrointestinal discomfort, such as hard stools.
[drugs effects] can be reduced to each other tetracyclines, quinolones suction branch.
Dosage for adults, oral: 1 to 2 / times, meal 1 ~ 2h, improper stomach before going to bed or to make clothes, not cross the 14 / day.
Precautions Pregnancy, breast-feeding women, babies and the spacious re-used with caution in renal dysfunction. Permanent taking, shall be determined duration of blood magnesium, aluminum content.
alkaline bismuth nitrate (bismuth nitrate)
Bismuth Subnitrate
[agents specification] tablet: 0.3g, 0.5g.
elated stomach tablets (Lewei membrane Roter): Each gel bismuth nitrate 0.3g, magnesium carbonate 0.4g, Sodium bicarbonate 0.2g, Franz buckthorn rind 0.025g.
[indications] gastroenteritis,
Nike Air Jordan kid shoes, peptic ulcer and diarrhea, also used for amoebic dysentery.
[] gastrointestinal adverse response reflecting the function of stagnation and detriment of desire, can present a high dose Eve Jagged white albumen hyperlipidemia.
fail narcotic interactions with carbonate, iodide salts and organic compatibility of use.
Dosage Oral: 0.3g ~ 1.2g / time, 3 times / day. Happy stomach tablets, 2 / 3 times / day, meal is served to retain the quantity of an / second.
] [Note for pregnancy Category D. Constipation, the absence to avoid nitrite poisoning. Of bacterial enteritis are warned to use moderation after infection.
bismuth potassium citrate [base] (colloidal bismuth subcitrate)
Bismuth Potassium Citrate
[agents specification] tablets or granules: 110mg;
bismuth compound mixture (stomach ulcer Ling): 100ml: 2.4g ~ 3.2g.
[indications] gastric and duodenal ulcers.
Pharmacokinetics] can accessible be absorbed along the absorbent tract. After absorption of major trace Bi Yan Man is the liver, kidneys and other constructs in mandate to list for a heap of renal delivery, and inferior leakage via the process of the kidneys.
Adverse reactions can be caused by tongue and stool stained dark, taking old population may have ammonia scent, occasional nausea.
[drugs] should not influence each other at the same time into the service of breast and antacids.
Dosage: oral tablets, 1-2 tablets / time, 4 times / day, before banquet or before Juefu; blend, 5ml ~ 10ml / time, 3 to 4 times / day, watertight with 1 to 4 times after loosen, before dinner or before bedtime; Granules: 1 pouch / second, 3 to 4 times / day, of water, blunt, half an hour before a meal or before bedtime; course of 4 to 6 weeks.
Precautions should be cutback of renal dysfunction to avoid toxicity.
bismuth pectin gel stature [base] (Weimin, elementary bismuth pectin)
Colloidal Bismuth Pectin (Weimin)
[agents specification] capsules made dose: 50mg.
[indications] gastric and duodenal ulcers, also used in chronic superficial gastritis and so on.
Dosage fasting oral, mature, 150mg ~ 200mg / time, 3 to 4 times / day.
Precautions should be reduction of renal dysfunction to avoid toxicity.
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