2004 年 12 months to December 2005 in our hospital in patients with congestive heart failure hospitalized a total of 62 patients,
abercrombie france, male 40 cases, 22 females, aged 42 to 78 years, average 58.2 years old. Including coronary heart disease in 24 cases,
abercrombie paris, 12 cases of dilated cardiomyopathy, hypertensive heart disease in 18 cases, six cases of rheumatic heart disease, diabetes and heart disease in 2 cases. According to the New York Heart Association (NYHA) functional class standards are divided into grade Ⅱ ~ Ⅳ class,
abercrombie paris, LVEF
all patients with diuretics, digoxin and angiotensin-converting enzyme inhibitors conventional therapy, heart failure (CHF) in stable condition were randomly divided into two groups : ① low-dose group: conventional treatment of heart failure, carvedilol on the basis of Jiaka Wei (Beijing Juneng Pharmaceutical Co), 2.5 mg, 2 times / d. ② high-dose group: conventional heart failure therapy based on the use of carvedilol from the 2.5 mg, 2 times / d, each 2 W 1-fold increase in dose to the target dose of 10 mg, 2 times / d or maximum tolerated dose ( sober resting heart rate should not be
observation and treatment after 6 months, two groups of patients with heart rate, cardiothoracic ratio, LVEF and cardiac function changes.
1.2 Methods
1 Materials and Methods
variety of congestive heart failure is the performance of end-stage heart disease. Generation of β-blocker carvedilol (Carvedilol, trade name: Network Germany) in a number of large-scale treatment of congestive heart failure in clinical trials is considered a promising drug. This paper discusses the application of different doses of carvedilol in patients with congestive heart failure therapeutic effect.
Different doses of carvedilol in patients with congestive heart failure efficacy
Author: Guo Jiangping Xiu-Wen Wang Source: Published 05 -01-23 view: times Abstract observe different doses of carvedilol in patients with congestive heart failure. Methods: 62 cases of congestive heart failure were randomly divided into two groups: low-dose group on the basis of conventional heart failure therapy Jiaka Wei carvedilol 2.5 mg, 2 times / d; high dose group in the conventional treatment of heart failure based on the carvedilol 2.5 mg,
sac hermes birkin, 2 times / d, each 2 W 1-fold increase in dose to the target dose or maximum tolerated dose. Were treated for 6 months. Results: After treatment, heart rate, cardiothoracic ratio, left ventricular ejection fraction (LVEF), cardiac function before treatment were significantly different (P <0.05), between the two groups are also significant differences (P <0.05 ). Conclusion: Carvedilol treatment of congestive heart failure, high-dose than low dose significantly improved cardiac function and increased LVEF.
1.3 OUTCOME MEASURES
Key words carvedilol Congestive Heart Failure
data are mean ± standard deviation (x ± s) said, before and after treatment and were used between the two groups t test, P <0.05 to have significant differences.
1.1 General Information
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